[img_inline align=”right” src=”http://padnws01.mcmaster.ca/images/Farncombeentrance08.jpg” caption=”Entrance to the Farncombe Family Digestive Health Research Institute. Image courtesy of FHS. “]A $15 million gift today launched a new research institute at the Michael G. DeGroote School of Medicine at McMaster University which will work towards the causes and cures of digestive diseases.

The Farncombe Family Digestive Health Research Institute will have a research focus on understanding the causes of common gastroenterology conditions, particularly inflammatory and other bowel diseases, with particular attention on the role of the intestinal microbial environment. This research will generate new therapeutic approaches to the disorders which affect more than 2 million Canadians and impact many aspects of health.

The new institute has been initiated by the Farncombe family of Oakville. They have donated $15 million to provide capital for new facilities, as well as the creation of endowed leadership positions, and the development of a team of young researchers.

The institute will build on a successful digestive health research program developed at the university for more than 25 years, considered one of the top 10 gastroenterology research groups in the world. An internationally-renowned 'super star' in the field has been attracted as its inaugural director. John Wallace, a pharmacologist and founder of two pharmaceutical companies, is currently at the University of Calgary, and will take the Institute position on January 1, 2009.

“We sincerely appreciate the leadership of the Farncombe family,” said Peter George, president and vice-chancellor of McMaster University. “Their gift is the fourth largest gift ever to a Canadian medical school. Three of these four gifts have come to the Michael G. DeGroote School of Medicine, which attests to the world-renowned work being done here.”

“The Farncombe Family Digestive Health Research Institute will greatly enhance our capacity to help the thousands who suffer from inflammatory bowel disease.”

Kevin Glasgow, CEO of the Crohn's and Colitis Foundation of Canada, said there is a profound need for additional research, as Canada has amongst the highest prevalence rates for Crohn's disease and ulcerative colitis in the world.

“McMaster is already robust as a world leader in digestive health research, and from its young researchers has spawned the leaders of many other important gastrointestinal research centres. This will solidify its pre-eminent role.”

He called John Wallace a 'super star', adding: “Dr. Wallace is one of Canada's – and the world's – pre-eminent gastrointestinal researchers.”

John Wallace said: “I am delighted to be joining one of the premier digestive disease research groups in the world. The generosity of the Farncombe family will allow us to build on the existing excellence, achieving our goal of developing better therapies and cures for many chronic digestive diseases.”

The Farncombe family initially gave $3.5 million in 2004 to the intestinal diseases research program at McMaster, to establish a gnotobiotic or sterile laboratory unique in Canadian universities, as well as an endowed professorial chair, the Farncombe Family Chair in Inflammatory Bowel Disease. That gift subsequently prompted more than $21.5 million in research grants; investments in additional facilities including DNA sequencing equipment and the allocation of two senior scientist positions, as well as the arrival of international graduate students attracted by its research programs.

The $15 million gift announced today will provide:

“This is a fascinating area of study. At a time when we hear of deadly digestive infections such as Listeria, there is increasing evidence that some infectious agents are required for the body to maintain health,” said John Kelton, the dean and vice-president of the Faculty of Health Sciences and the dean of the Michael G. DeGroote School of Medicine.

“In other words, healthy individuals require a balance in the type and number of bacteria that live within their bodies. The Farncombe Family's remarkable gift will allow McMaster to be the first Canadian university to systematically address this important question by studying the effects of bacteria on the entire well-being of humans.”

Development of a young team of researchers is important, said Steve Collins, a founding leader of the digestive research program at McMaster and now associate dean for Research for the Faculty of Health Sciences.

“We are very grateful to the Farncombe family for their continued support of our research,” he said. “This gift will enable us to fully exploit our large germ-free laboratory which is essential to better understand how intestinal microbes can initiate and maintain chronic disease. We now have a unique infrastructure that will attract scientists of the highest calibre and enable us to go beyond existing boundaries in our search for the causes of functional and inflammatory bowel diseases.”